FEATURES OF VEGETATIVE REGULATION OF CARDIAC RHYTHM IN RATS UNDER THE INFLUENCE OF FINE-DISPERSED AEROSOL (VAPOR) COMING FROM THE DEVICE THAT SIMULATES THE ELECTRONIC CIGARETTE

The aim of the study was to study the functional state of the autonomic nervous system in rats after inhalation of highly dispersed aerosol from the Electronic Nicotine Delivery System. The study was conducted on 35 mature rats. The inversion of sensitivity of the autonomic nervous system in rats under the action of a highly dispersed aerosol (vapor) coming from the device simulating an electronic cigarette was revealed. Single exposure of the aerosol (vapor) of animals were recorded by a functional imbalance of the autonomic regulation of the heart rhythm with a predominance of parasympathicotonia and failure neurohumoral autoregulation myocardial on the background of centralization of control heart on the background of pronounced fluctuations of the adrenergic component. With increasing exposure to multiple inhalations of aerosol (vapor), there is a pronounced maladaptation of animals, which is associated with dysfunction of the autonomic nervous system in the form of reduced activity of the parasympathetic segment and increase the tone of the sympathetic segment.