SYNTHESIS AND CHARACTERIZATION OF SOME NEW MONO AND BIS CYCLIC AZETIDIN-2-ONES

This study is concerned with the synthesis and characterization the 3-methoxy/3,3-dithio dipropyl mono and biscyclic azetidin-2-ones 3 (a-d). These compounds 3 (a,b) were prepared by reacting methoxyacetyl chloride with the appropriate imines 2(a,b) in the presence of triethylamine in dry dichloromethane under nitrogen atmosphere at -10˚C and the compounds 3 (c,d) were prepared by reacting 3,3'-dithio dipropanoic acid with the appropriate Schiff’s base 2 (c,d) in the presence of triethylamine with phosphorusoxychloride in dry dichloromethane under nitrogen atmosphere at -10˚C. The active acid chloride reacts with triethylamine to generate corresponding ketene in situ which further reacts with Schiff’s base to furnish corresponding 3-methoxy/3,3-dithio dipropyl mono and biscyclic azetidin-2-ones 3 (a-d).