Evaluation of Dopamine Receptor Integrity after Sevofl urane Exposure in Neonatal Rat Brain Using Positron Emission TomographyJournal
: Global Journal of Anesthesiology (Vol.5, No. 1)
Publication Date: 2018-01-18
Authors : Qi Yin Merle G. Paule Tucker A. Patterson Fang Liu Charles M. Fogle Scott M. Apana Marc Berridge William Slikker Jr Cheng Wang; Xuan Zhang;
Page : 001-006
Keywords : Sevo fl urane; Dopamine receptor; Positron emission tomography; Fallypride; General anesthetic;
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Aims: The volatile general anesthetic sevofl urane is commonly used across all ages in the clinic. Sevofl urane-induced neurotoxic effects on the developing dopaminergic system are still unclear. The aim of this study was to evaluate the integrity of the D2/D3 receptor in developing rat brain utilizing molecular imaging techniques.
Method: Positron Emission Tomography (PET) coupled with Computerized Tomography (CT) approaches were used to evaluate the effects of developmental sevofl urane exposure on D2/D3 receptors in rat pups. The PET radiotracer, [18F]-fallypride, was used to examine whether dopamine receptors were affected by prolonged sevofl urane-exposure during the brain growth spurt. Six postnatal day (PND) 7 rats in the experimental group were exposed to sevofl urane at the clinically-relevant concentration of 2.5% (v/v) for 8 hours, and an equal number of control animals were exposed to room air for 8 hours. MicroPET/CT scans were sequentially collected on PNDs 14, 21, 28, and 35.
Last modified: 2018-11-09 20:52:47