In silico Molecular Docking Studies of Some Phytochemicals against Dipeptidyl peptidase 4Journal: International Research Journal of Pharmacy and Medical Sciences (IRJPMS) (Vol.1, No. 6)
Publication Date: 2018-11-10
Authors : Ahmed H.A Alkali I. Y Mahmud A.F;
Page : 65-68
Keywords : Dipeptidyl peptidase-4; Phytochemicals; AutoDock vina.;
Background of study: Dipeptidyl peptidase-4 (DPP-4) is an enzyme involved in degradation of both Gastric inhibitory polypeptide (GLP-1) and Glucagon-like peptide (GIP). The inhibition of this enzyme DPP-4 increases the level of insulin released and thereby decreases the blood glucose level by insulin mediated cell glucose transport mechanism. Therefore, it is a potential target for development of novel drug for treatment of type 2 diabetes. Objective: To determine the potential of some phytochemicals to inhibit DPP4 enzyme Method: Phytochemicals namely plumbagin, Quercetin, Isovitexin, mangiferin, Syringin, Lupe-20-ene-3-one, 7-(2-hydroxyethyl)-3-methyl-8-(1- phenylethylideneaminoamino) purine 2, 6-dione, Diosmetin and β sitosterol and sitagliptin a standard drug were docked against DPP4 using AutoDock vina, results were analyzed using binding energy. Results: Among the phytochemicals (ligands) docked in this study, 5 namely; Tiliroside, Diosmetin, Purine-2, 6-dione, isovitexin, and mangiferin showed lower binding energy than the standard dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin Conclusion: According to the findings of this study, Tiliroside, Diosmetin, Purine2, 6-dione, isovitexin, and mangiferin can serve as potential source of future antidiabetic drugs.
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Last modified: 2018-11-10 22:00:08