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Antioxidant Activity of Heterocyclic Compounds Derived from 4-(4-Acetamidophenyl)-4-oxobut-2-enoic Acid

Journal: International Journal of Science and Research (IJSR) (Vol.3, No. 5)

Publication Date:

Authors : ; ; ; ; ;

Page : 1274-1282

Keywords : Pyridazinone; Diazepine; Benzothiazinone; Quinoxalone; Piperazine; Benzoxazinone; Furanone; Antioxidant activity;

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4-(4-Acetamidophenyl)-4-oxobut-2-enoic acid 1 and / or its aza Michael adduct 2 were efficiently utilized to construct novel various heterocycles including derivatives of furanones (3a-c & 14), pyridazinones (4-6), diazepine (7), piperazine (8), oxazine (9), oxazole (10a), thiazole (10b), benzo-, [-diazin, -oxazin, -thiaz-]-ones (11a-c). Conduct (11c) with NH2-NH2..H2O in boiling ethanol and / or NH2OH.HCl in refluxing pyridine provides the corresponding hydrazone and oxime derivatives 12a and 12b, respectively. The two latter compounds showed in vitro a high potent antioxidant activity, as well as, the aza Michael adduct 2e exhibited a moderate reducing antioxidant power.

Last modified: 2014-07-02 21:58:22