LEVEL OF BIOMARKERS OF FIBROGENESIS AND EXCHANGE OF COLLAGEN IN THE URINE OF CHILDREN WITH VARIOUS VARIANTS OF VESICOURETERAL REFLUX REPAIR

Abstract. The vesicoureteral reflux (VUR) provokes development of nephrosclerosis in 48% of children with connective tissue dysplasia. Aim: Detection of clinical significance of biological markers of fibrogenesis (TGF-β1) and indices of collagen metabolism urine excretion in children with chronic pyelonephritis after conservative, endoscopic and operative correction of VUR for predicting the development of renal scarring was the aim of this trial. Material and Methods. 69 patients from 2 to 16 years with various variants of VUR (II-V grade) repair in a period of clinical-laboratory remission of pyelonephritis were examined. Results. We have found a significantly higher TGF-β1 (р<0,0001), free oxyproline (р<0,0000) and peptid-binded oxyproline (р<0,0000) urinary excretion in children with VUR regardless of the method of repair in comparison with children of control group. Conclusions. Thus, urinary excretion of TGF-β1 and oxyproline fractions can be used as markers for the development of renal parenchyma scarring in children with VUR.