Protein Based on its Sequence or Structure to an Existing Protein FamilyJournal: International Journal of Science and Research (IJSR) (Vol.3, No. 5)
Publication Date: 2014-05-15
Authors : Manish Kumar; Ajay Prakash;
Page : 1582-1585
Keywords : Protein; PIR; SCOP; CATH; Pfam; Superfamilies;
To discover a new protein we have suggested some methods and also we have proposed how we can review of a protein to an existing protein family. We generally accepted that the three-dimensional structure of a peptide chain is determined by its amino acid sequence. Still, similar folds can have very different sequences. The ultimate task in sequence analysis is to predict the structure and function of a protein based on its sequence. When the protein of interest shares at least 30% amino acid identity with another protein, then these two proteins generally exhibit similar three-dimensional structure . But when the proteins have the similar structure but divergent sequences, then the consensus sequence motifs can be used to assess the function of an unassigned sequences. Then these consensus motifs usually correspond to the residues interacting with the cofactors, substrate, or other proteins. In this paper we have also done statistical analysis (through SPSS) to classify identical proteins and Evolutionary Relationship and Structural similarity of the proteins.
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Last modified: 2014-07-03 17:12:14