Prophylactic effects of vitamin E and coriander (Coriandrum sativum) extract on lead-induced testicular damage in Swiss albino mice

Lead toxicity is the vital issue in the developing countries that causes serious health hazards in animals and humans. Prophylactic effects of vitamin E and coriander (Coriandrum sativum) extract on lead-induced testicular damage in Swiss albino mice were investigated in the present study by gross and histological studies in five groups (control, lead intoxicated, vitamin E-treated, coriander-treated, vitamin E and coriander-treated). Treatment was done for 42 days. In the present study, weight and length of left and right testes were significantly (p<0.05) reduced in lead-intoxicated mice in comparison to the control group. Lead acetate was found to cause separation of primary spermatocyte from spermatogonia, morphological changes of seminiferous tubule and irregular arrangement of spermatogenic cells in the seminiferous tubules of testis. Vitamin E and coriander extract were found effective in the treatment of lead intoxicated mice and testes histology were found normal. Combined antioxidative action of vitamin E and corriander extract was also found effective in the treatment of lead intoxicated mice. The present investigation may serve as baseline data about adverse effects of lead toxicity and efficacy of vitamin E and coriander extract against lead toxicity. Further research need to be done to isolate and purify the active principle involved in the antioxidant activity of this plant.