Study the Association of Serum Level of βHCG and Estradiol in the Pathogenesis of Hyperemesis Gravidarum

Background: The precise mechanism underlying hyperemesis gravidarum, a bothersome condition that affects pregnant women, remains unclear, but appears to be multifactorial. The Purpose: To study the association of serum level of βHCG and Estradiol in the pathogenesis of hyperemesis gravidarum (HG). Patients and Methods: From the outpatient clinics & emergency department of Al-Zahra’ Teaching Hospital for Gynaecology & Obstetrics / Kufa University we recruit forty five pregnant women with hyperemesis gravidarum and forty five normal pregnant women as a control group. Serum levels of βHCG and Estradiol using VIDAS method were measured for patient group and control group. Statistical analysis of the datas was done. Results: Regarding the forty five pregnant patients with hyperemesis gravidarum, their mean age was 24.96 years, SD ± 4.719 & p-value =0.752, while the control group, their mean age was 25.29 years, SD± 5.225. Twenty six patients of the forty five (57.8 %) were having serum βHCG above the upper limit of the normal pregnancy (their serum βHCG mean was 137909, SD ± 45536 & p-value =0.000), while five of the forty five (11.1 %) pregnant women of the control group were having serum βHCG above the upper limit of the normal pregnancy (their serum βHCG mean was111181, SD ± 44193 & p-value =0.000). Thirty nine patients of the forty five (86.7 %) were having serum Estradiol level more than the upper limit of normal pregnancy (their serum Estradiol mean was 2090, SD ± 1766 & p-value =0.000), while twenty two of the forty five control group (48.9 %) were having serum estradiol level more than the upper limit of normal pregnancy (their serum Estradiol mean was 984, SD ± 263 & p-value =0.000). Conclusion: High serum levels of βHCG and Estradiol are associated with hyperemesis gravidarum.