Possibilities of personalized therapy in patients with chronic pelvic pain and inflammatory diseases of the pelvic organs

The aim of our study was to create a pathogenetically determined systemic approach to improve the treatment and the psycho-emotional state of a woman with chronic pelvic pain and inflammatory diseases of the pelvic organs through the individualization of therapeutic and rehabilitation tactics on the basis of the study of immune-hormonal relations, and psychopersonal characteristics of thematic patients. A comparative evaluation of the cytokine (IL-10, IL-6, TNF-α) and hormonal profile (luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, progesterone, prolactin, cortisol) was carried out as well as; monitoring of pain and psycho-emotional disorders of the dynamics of observation. In the dynamics of observation after the treatment for 6 months it was noted: a decrease in the pro-inflammatory activity of the cytokine profile: IL-6 by 43.28%, TNF-α by 63.27%; recovery of hormonal ratios – in 76% of women; 88% of patients identified a significant improvement in general and psychoemotional state; reduction of reactive anxiety and depressive disorders to normal values was determined in 84% of patients; regression of pain syndrome to the minimum indices according to the VAS scale was determined in 96% of patients. This demonstrates the effectiveness of personalized therapy and the possibility of expanding the therapeutic - diagnostic algorithm in patients with chronic pelvic pain.