Acute scrotum caused by an extraspermatic venous thrombosis associated with G20210A prothrombin gene mutation in a pediatric patient: A case report

Thrombosis of an extraspermatic blood vessel has been reported to be an unusual cause of acute scrotum. We describe the case of a 7-year-old boy who presented with an acute painful left scrotal swelling. Imaging demonstrated a heterogeneous left scrotal mass, which was surgically resected. The anatomopathologic study revealed a thrombosed vascular structure. Three months later, another extraspermatic venous thrombosis occurred and was also resected. A complete thrombophilia study was done. A G20210A prothrombin gene heterozygous mutation was identified as the cause of the thrombotic event. A venous thrombosis should be considered as a possible cause of acute scrotum in European Caucasian patients, due to its increased prevalence. We reviewed the G20210A prothrombin gene mutation, which is associated with thrombosis.