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Association of the Treatment Induced Clearance of Hepatitis C Virus Infection with the IL28B Gene Polymorphisms
Journal: Archives of Hepatitis Research (Vol.1, No. 1)Publication Date: 2015-12-30
Authors : Aleksandar Sikole Pavlina Dzekova Vidimliski Igor G Nikolov Nadica Matevska Geshkovska Yana Boyanova Nina Nikolova Grigore Romanciuc et.al.;
Page : 005-008
Keywords : IL28B gene; Single nucleotide polymorphisms; Chronic hepatitis C; Pegylated interferon α; Ribavirin; Sustained viral response;
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Abstract
Hepatitis C virus (HCV) has often been referred to as the “silent virus,” as most HCV infections are clinically silent until the disease reaches a late stage, which often occurs several decades after initial infection. Although a variety of host factors play a role in eradication of HCV, only 15%-25% of adults spontaneously clear the infection [1]. The remaining 75%-85% of patients continue to have persistent viremia, life-long HCV infection, chronic hepatitis C [2].
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Last modified: 2019-04-12 18:54:43