Microwave Irradated Synthesis, Characterization and Evaluation for their Antibacterial and Larvicidal Activities of some Novel Chalcone and Isoxazole Substituted 9-Anilino Acridines

Introduction: Chalcone, isoxazole and acridines have diverse biological activities. A series of novel chalcone and isoxazole substituted 9-anilinoacridines were synthesized for their antibacterial, larvicidal, activities. Methods: A series of novel chalcone and isoxazole substituted 9-anilinoacridines (3a-h and 4a-h) were synthesized from 9-chloroacridine by microwave irradiation method. The antibacterial evaluation was performed by cup-plate method and screened for their larvicidal activity by larval bioassay method. Result: The compounds 3d, 3e, 3f, 3h, 4d, 4f have significant antibacterial activity against Gram +ve bacteria like Staphylococcus aureus, Bacillus megaterium, and Gram –ve Escherichia coli, Klebsiella pneumoniae at 25μg/ml. Compounds 3c, 3f, 4a, 4f have significant larvicidal activity against culex and anopheles species at LC50value of 17-36ppm.