Syndrome “Eclampsia” Mechanism of Pregnant Cows and Effectiveness of Antioxidant Preparations | Biome Grid

800 dairy cows and heifers of highly productive Holstein- Friesian breed, black and mottled and Simmental breeds with an average annual milk production of 6700 kg participated in experiment. Each group of animals was divided into two subgroups. Down calver heifers and cows in dry period were injected with organ selenium preparations intramuscularly at a dose of 0.01 ml per 1 kg of body weight on the 15th and 45.th days, for 30 days with 72 hours interval. The first experimental group received the preparation «Immunoseyv®», the second – «Selenolin®» and the control group didn't use preparations. Interhormonal relationships system and LPO-AOD system imbalance of pregnant cows leads to the development of «eclampsia» syndrome in the last third of pregnancy. This pathological state of clinical manifestation is registers against the background of functional insufficiency placental system and non-enzymatic antioxidant protection level. Compared with clinically healthy animals in concentration of progesterone below a blood 2.2–2.5 times (10.5 ± 2.09 vs. 24.7 ± 4.62 ng/ml), testosterone – 1.85 times ( 0.7 ± 0.09 vs. 1.3 ± 0.22 ng/ml), estradiol – by 27.0 % (215.0 ± 17.9 vs. 273.4 ± 38.4 pg/ml), cortisol – at 34.0–52.8 % (24.4 ± 3.01 vs. 32.7 ± 5.79 ng/ml) vitamin E – 45.4 %, vitamin C – 20.8 %. MDA content larger than that in healthy animals by 43.3 % (from 1.04 ± 0.14 to 1.49 ± 0.12 mmol / l), the stable metabolites N0* – 31.9 %, MPO activity – 26.6 %, catalase – by 17.3 %, triglycerides – 2.2 times, the lactic acid – 2.5 times, the sorption ability of erythrocytes – 55.1 %. Eosinophilia and thrombocytopenia accompanied these changes. Organ selenium preparations double assignment to parenteral clinically healthy cows in dry period for prevention «eclampsia» syndrome and correction metabolic disorders prevents development of obstetric pathology in 92.8 % of the animals, exceeding to 23.7 % index of control group. Applying «Immunoseyv®» selenium-containing preparation to animals with preeclampsia clinical symptoms and subclinical eclampsia reduces detention afterbirth in 3.2 times and postnatal pathology on 10.0 %.