PECULIARITIES OF EXPERIMENTAL ANIMALS’ BEHAVIORAL REACTIONS UNDER THE CONDITIONS OF LONG-TERM ORAL ADMISSION OF INDUSTRIAL URANIUM ORE DUST TO THE BODY

The dynamics of animals' higher nervous activity disturbances and bioaccumulation of uranium in tissues under the conditions of prolonged oral admission of industrial uranium ore dust (UOD) at doses of 25 and 50 maximum exposure concentrations (MPC) to the body were studied. In the early periods after the admission of UOD into the animals' body, the maximum concentrations of uranium are determined in the kidneys, in the late period – in the bone tissue, while the content of uranium in organs and tissues correlated with the dose of UOD. On the background of an increased concentration of uranium in the rats' brain with chronic admission of UOD in the body, a steady alarm state is formed and terms of retention of acquired passive avoidance skills are reduced. The data obtained in this work indicate the presence of long-term effects of radiotoxic exposure of UOD, which dictates the expediency of long-term observation of the behavioral reactions of animals