In-Vivo Antioxidant Potentials Of Citrullus Colocynthis Schard In Rotenone Induced Parkinsons Disease Animal Model.

the current study aims at investigating the Neuroprotective efficacy of an herb INDRAVARUNI Citrullus colocynthis Schard by estimating its effect on endogenous antioxidant molecules in rat brain samples using Rotenone induced Parkinsons disease animal model. 42 healthy male Wistar rats were selected for the study and were divided into 7 groups. Before inducing Parkinsons disease the experimental animals were acclimatized for three days. The Rotenone solution was administered at 2.5mgkg body weightday intraperitonealy to all the groups except for the normal control group which received only the vehicle DMSO Triester F 810. The respective treatment groups received their treatment from the day of starting of rotenone injection. Animals developing debilitating phenotype limiting their mobility feeding or grooming were sacrificed and brain samples procured from them. Ultimately the rats surviving till the 9th day were also sacrificed on 10th day and brain samples procured which were used for estimating MDA SOD CATALASE and GSH levels. The BID and TDS dosage groups showed maximum efficacy in endogenous antioxidant parameters.