Therapeutic Potential of Phthalimide Derivatives: A Review| Biomed Grid

Phthalimides belong to the group of cyclic imides and have as common chemical characteristic two two carbonyls bound to the same nitrogen. Such compounds are obtained by various organic synthetic processes, generally using phthalic anhydride as the precursor. Because they present various biological activities such as antinoceptive, anti-inflammatory, antitumor, anti-convulsant, antimicrobial, among other actions, these molecules have been object of study in several research centers worldwide. This review article is intended to provide highly relevant information on the biological activities of these compounds and their mechanisms of systemic action that have already been elucidated. The articles used in these studies were obtained through the Internet [from Elsevier, NCBI and Science direct] in the period of July and August of 2018. Several compounds were identified acting in various pharmacological actions. The phthalimides and their derivatives studied in this study presented individual molecules, but also conjugated with other pharmacophoric groups, in order to improve their pharmacokinetic and pharmacodynamic aspects and thus generate better therapeutic responses. In spite of the studies with phthalimides, it is still necessary to investigate, mainly the mechanisms of action of these molecules, explaining all the interactions that they can make, so that new and more audacious studies can be carried out.