PREPARATION AND IN VITRO EVALUATION OF OPTIMIZED FORMULATION OF BI- LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATEJournal: International Journal of Advanced Research (Vol.7, No. 5)
Publication Date: 2019-05-01
Authors : Sreedhar Ranjan Das Bibhuti Bhusan Panigrahi; Manoj Kumar.Pani.;
Page : 890-896
Keywords : Sucralfate MetoprololSuccinate Bi-layered Floating Tablet GRDDS.;
Objective: The present study based upon the preparation and in vitro evaluation of optimized Bi layered floating tablet (OSFMS)having tablet weight of 400 mg.(214.88 mgofsucralfate& 186 mg of Metoprol succinate). Method: Selection of the formulation, pre compression study, preparation of tablet and in vitro evaluation of tablet. Result: In presence of Lactose MFL, MCC PH 101, Sodium Bicarbonate, Polysorbate 80, Cross povidone of majore amount in Sucralfate layer and in presence of HPMC K 100 M, Sodium Bicarbonate, Eudragit RSPO, Na CMC ,Sodium alginate, HPC, Ethyl Cellulose of majore amount in Metoprolol Succinate layer it produce (OSFMS)tablet having weight of 400 mg.(214.88 mgofSucralfate& 186 mg of Metoprol succinate) produced average drug release 99.92 % and DT of Sucralfate was 1.04 min at acid medium of stomach and TFT of Metoprol Succinate at upper intesine was > 24hours. Conclusion: The optimized formulation of Sucralfate and Metoprolol Succinate (OSFMS) may be considered as a better formulation as Gastro Retaintive Drug Delivery System..
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