A Formulation and Characterization of Metformin Loaded Floating Tablet by Using Natural Polymer

Diabetes is a chronic metabolic disease characterized by high glucose level in the blood. Sustain release gastro retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of gastrointestinal tract and improve the bioavailability of medication that is characterized by narrow absorption window. Gastro retentive floating drug delivery system of metformin HCL, an anti-diabetic drug with an oral bioavailability of only 50% (because of its poor absorption from lower gastrointestinal tract) have been designed to increase its residence time in the stomach without contact with the mucosa was achieved through the preparation of floating tablet by direct compression technique, by using Guar gum as release retardant, and NaHCo3 as gas generating agent to reduce floating lag time. Floating tablet were evaluated for hardness, Friability, Weight Variation, Drug content, Floating properties and In-vitro release pattern.