Quantum Chemical Calculation, Hemolytic Effect and Anti-Denaturation Activity of Schiff Base Ligand

A Schiff base ligand 2-[(1E)-N-{2-[(2-{(Z)-[1-(2-hydroxyphenyl) ethylidene] amino}ethyl)amino]ethyl}ethanimidoyl]phenol was selected for quantum chemical calculations and biological effects evaluations. The quantum calculation showed stability and reducing character of the Schiff base. In addition, in vitro hemolytic and anti-denaturation activities were evaluated. The Schiff base showed no toxic effect (hemolytic activity) in vitro. For anti-denaturation effect, the Schiff base exhibited significant activity against denaturation of egg proteins with I% decreasing with increase of temperature. In conclusion, results of the present investigation indicate that the ligand can be a potential anti-denaturant agen