Acidic Pharmaceuticals Simultaneous Removal from Water Sample by Magnetic Ionic Liquid Nanoadsorbent 1-Butyl-3-Aminopropyl Imidazolium Tetrachloroferrate Functionalized Graphene Oxide GO-sBapim) FeCl4 | Biomedgrid

This paper evaluated the removal efficiency of twelve acidic pharmaceuticals by microextraction with 1-butyl-3-aminopropyl imidazolium tetrachloroferrate functionalized graphene oxide GO-(Bapim)FeCl4 nanocomposite. The acidic pharmaceuticals studied were salicylic acid (SYL), clofibric acid (CFA), ibuprofen (IBP), acetaminophen (AAP), gemfibrozil (GFB), fenoprofen (FNP), naproxen (NPX), triclosan (TCS), ketoprofen (KTP), diclofenac (DOF), fenofibrate (FFB), and indomethacin (IDM), which are commonly used as analgesic/anti-inflammatory agents or lipid regulators. The proposed procedure complies with the principles of the green chemistry, since it uses low volumes of easily synthesized MILsbased magnetic extracting phases avoiding the use of toxic solvents. The analytical procedure for the determination of acidic pharmaceuticals in aqueous matrices included solid phase microextraction, liquid chromatographic separation and detection by a triple-quadrupole mass spectrometer. Taking into account the main experimental variables involved, the results obtained are accurate and highly reproducible. The low-cost approach is straightforward, environmentally safe and exhibits high enrichment factors and absolute extraction percentages and satisfactory recoveries.