Some Links of the Pathogenesis of Endogenous Intoxication in the Mother’s Organism with AВO Immunization | Biomedgrid

According to foreign researchers, hemolytic disease takes the 2nd place among the causes of stillbirth, and hemolytic disease of the newborn is diagnosed in 0.5% of newborns [1]. Pregnant women with isoimmunization develop endogenous intoxication syndrome, which contributes to the development of placental dysfunction, determines the high frequency of pregnancy complications, morbidity and mortality from hemolytic disease of the newborn in newborns [2]. Recent studies have shown that in the blood of pregnant women with immunization there is an increase in the blood content of pregnant women with biologically active substances (toxic metabolites), impaired function of the biotransformation organs and, as a result, the development of endogenous intoxication syndrome at all levels of the mother-placenta-fetus system. Toxic metabolites (biological active substances), in turn, are one of the activators of the immune system, and precede the biosynthesis of antibodies [3].