Evaluation of Oxidative Stress Parameters in Liver in Pentylenetetrazole - Induced Acute and Chronic Epilepsy Model in Rats | Biomedgrid

Epilepsy occurs due to periodic and spontaneous excessive electrical discharges of cerebral, cortical and subcortical neurons. Epilepsy affects about 1% of the global world population. In epilepsy, the formation of reactive oxygen species (ROS) in the brain usually increases with recurrent seizures. The aim of this study was to evaluate the levels of oxidative damage in the chronic and acute epilepsy model by measuring AST and ALT enzyme levels from serum samples and CAT, SOD and TBARS levels in liver tissues. In our study we found that, serum AST levels of acute epileptic model group were found to be significantly higher than control and chronic epileptic model group (p<0.05). SOD levels of chronic epileptic model group were found to be significantly higher than acute epileptic model group and control groups (p<0.05). CAT levels of chronic epileptic model group were found to be significantly lower than control group (p<0.05).