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The Adrenergic Mechanism in the Implementation of the Cholinergic Anti-Inflammatory Pathway | Biomedgrid

Journal: American Journal of Biomedical Science & Research (Vol.6, No. 1)

Publication Date:

Authors : ;

Page : 43-46

Keywords : cholinergic anti-inflammatory pathway; sepsis; β2ARs agonist; α7nAChR agonist; proinflammatory cytokines; AJBSR;

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Experiments on random-bred albino mice showed that application of β2ARs agonist (hexaprenaline sulfate, 1,5 μg/kg, a single dose) and α7nAChRs agonist (GTS-21, 15 mg/kg, a single dose) cause a significant decrease in the mortality of mice from experimental sepsis (i.p., E. coli O157:H7) when it is modeling 2h after using these drugs due to a decrease of the concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6 (implementation of the cholinergic anti-inflammatory pathway). It has been experimentally established that the adrenergic mechanism (action of β2ARs agonist) is an important component in the implementation of the cholinergic anti-inflammatory pathway. The combined use of β2ARs and α7nAChR agonists determines their additive effect.

Last modified: 2019-12-02 14:13:42