THE STATE OF NEUROTRANSMITTER SYSTEMS IN SOME PARTS OF THE RAT BRAIN IN ACUTE COMPLEX INTOXICATION WITH MORPHINE AND ALCOHOL

Background. In narcological practice, the problem of opioid dependence complicated by alcoholism occupies one of the main positions among serious diseases. Purpose. To study the parameters of dopaminergic and serotonergic systems in the cerebral cortex and the striatum of the rat brain with a single comprehensive administration of morphine hydrochloride and ethanol. Material and methods. The experiment was carried out on male rats. The following groups were formed: the controls, those with acute alcohol intoxication, those with acute morphine intoxication, those receiving morphine followed by ethanol administration 12 hours later, those receiving ethanol followed by morphine administration 12 hours later. Results. A joint single administration of ethanol and morphine led to changes in the serotonin system in the cerebral cortex and in the striatum. To a lesser extent these combinations of psychoactive substances influenced on the changes in the dopamine system in the studied brain regions. Conclusions. The combined use of surfactants can lead to unpredictable metabolic changes in the central nervous system.