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Journal: Journal of the Grodno State Medical University (Vol.18, No. 1)

Publication Date:

Authors : ;

Page : 17-20

Keywords : CD3+CD4+CD8+ T-lymphocytes; kidney graft dysfunction;

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Background. Double-positive CD3+CD4+CD8+ T-lymphocytes are signifcant in the immune response to various infectious agents. Pancreatic islet transplantation in the experiment characterizes CD3+CD4+CD8+ as a new biomarker for donor cells rejection. Objective. To study the indices of CD3+CD4+CD8+ double- positive T-lymphocytes before kidney transplantation in patients with early allograft dysfunction. Material and Methods. We examined 199 recipients who underwent kidney transplantation. CD3+CD4+CD8+ count was determined before transplantation. All the patients were divided into 2 groups: those with primary graft function (PGF) and those with graft dysfunction (PGD). A correlation analysis was performed between the values of CD3+CD4+CD8+ and the biomarkers indices of allograft function on the 7th day. Results. Before transplantation the CD3+CD4+CD8+ count was signifcantly lower in recipients with early allograft dysfunction as compared to the group with primary allograft function. The CD3+CD4+CD8+ indices were determined to predict the development of early allograft dysfunction. Conclusions. The CD3+CD4+CD8+ indices in recipients before kidney transplantation can be used to predict the development of early allograft dysfunction.

Last modified: 2020-03-17 18:39:04