COMPARATIVE STUDY BETWEEN VARIOUS PEDIATRICS DOSE CALCULATION FORMULAS: A CASE STUDY OF 12 YEARS CHILD FOR PARACETAMOL

In this piece of study one case evaluated relevant to the dose calculation in which six formulas utilized for calculation of optimal doses and comparison between these formulas as well as beauty of all formulas. The different formulas used like on the basis of age includes Young rules, Dilling rules, Bastedo rules, Crowling, on the basis of weight Clark and Majid formula used and for Body Surface Area Mosteller formula utilized. The result of the current study purports for one patient of Paracetamol dose in which Young formula result is 250 mg, Dilling 300mg, Bastedo 250mg, Crowling 270.9mg, on weight basis 278.5mg by Clark and Majid rule also 278.5 and 329mg by Mosteller Body Surface Area formula, the mean of the current result is 279.4mg that is nearest to weight formula considered as better and BSA formula shows 329mg that is in the category of therapeutic window because in British National Formulary Paracetamol dose ranges from 250- 500mg and some authors reported Dilling rule is good due to simplicity and brevity. The current study concluded Dilling rule is the simplest one, weight base is nearest to average range and the most appropriate formula is BSA but slight lengthy in calculation. Dose calculation play crucial role in clinical condition of the patient and proper formula should be selected in order to get better therapeutic outcomes.