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Protective Effects of Antioxidants Against Rheumatoid Arthritis-Induces Lipid Peroxidation and Glutathione Depletion

Journal: Albalqa Journal for Research and Studies (Vol.6, No. 2)

Publication Date:

Authors : ; ; ;

Page : 45-61

Keywords : Effects -Antioxidants.;

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The effects of rheumatoid arthritis (RA) and antioxidant therapy for 10 days with vitamin E, Vitamin C and vitamin A on serum lipid peroxidation (MDA content), glutathione (GSH) content, glutathione S-transferase (GST) activity, glutathione reductase (GSR) activity, both total and selenium dependent glutathione peroxidase (GSI-I-Px) activities were tested in 18 rheumatic patients. RA patients had increased MDA content, and index of lipid peroxidation, depleted GSH levels, elevated GST activity and inhibited GSR and GSI-I-GSI-I-Px activities, as compared to 20 healthy subjects. Supplementation with vitamin E decreased MDA content, elevated GSI-I levels, GSR and GSI-I-Px activities after 5 days of therapy. Vitamin C supplementation did so only after 10 days of therapy, while treatment with vitamin A showed no significant changes in these parameters compared to pretreatment levels The results suggest that antioxidant therapy may afford some protection against oxidative stress associated with RA

Last modified: 2020-04-20 15:57:40