INCIDENCE OF NEW ONSET DIABETES MELLITUS SECONDARY TO ACUTE PANCREATITIS: A SYSTEMATIC REVIEW REVIEW

Background and Aims: Patients who have an episode of acute pancreatitis (AP) frequently develop diabetes mellitus (DM) overtime. There ported incidence of DM after AP varies depending on the severity, etiology and the extent of pancreatic necrosis during AP. We performed a systematic review to determine the incidence of new-onset DM after a Pepisode(s) and compared the rate of DM in AP patients based upon different disease characteristics.(1) Method: A total of 50 patients were enrolled from government general hospital Kadapa India suffered from acute pancreatitis during January 2018 to July 2019. Results: The random-effects pooled incidence was 22.0% for DM. The DM incidence was higher in the populations that had a severe AP (SAP) episode than in those with mild acute pancreatitis (MAP) Patients that displayed pancreatic necrosis during the AP attack(s) had a higher frequency of DM than those without necrosis in addition, the pooled incidence of DM was higher after alcoholic compared to biliary AP. The incidence of insulin use after SAP and alcoholic AP was 21 and 18%, respectively, with very low heterogeneities. Conclusion: Patients with AP developed DM after discharge from hospital with a frequency of about 22%. SAP, alcoholic AP and acute necrotizing pancreatitis (ANP) were associated with increased incidence of DM. Assessments of severity, etiology, and pancreatic necrosis are critical for predicting DM development after AP.