ROLE OF MUTATION OF INSULIN RECEPTOR GENES IN THE DEVELOPMENT OF THE PHENOMENON OF INSULIN RESISTANCEJournal: Journal of the Grodno State Medical University (Vol.18, No. 2)
Publication Date: 2020-05-02
Authors : Nikonova L. V. Tishkovskiy S. V. Butrim O. S;
Page : 102-106
Keywords : insulin resistance; insulin; glucose; genes; mutation;
The mechanism of development of insulin resistance is not fully deciphered. Disorders that lead to insulin resistance can occur at the following levels of the insulin signaling pathway: pre-receptor (abnormal insulin), receptor (reduced number or affnity of receptors), glucose transport (reduced number of GLUT4 molecules), and post-receptor (signal transmission disorders) level. The article analyzes the signaling pathway of insulin, and considers the effect of gene mutations on signal transmission and glucose transport to the cell.
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