Evidence of health complications caused by mosquito coil smoke inhalation in mouse model

Direct exposure to mosquito coil smoke (MCS) is a regular event in the entire life of most tropical country peoples, although it has countable significant health implications. However, noxious effect of mosquito coil smoke exposure on living being remains elusive. Herein, to address the mosquito coil smoke implication on health, Swiss albino mice were directly used to detect the health indicator alteration upon MCS administration as experimental model. In total 45 albino mice were grouped and exposed with MCS in two different time period viz, short time for 20 days and long time for 40 days. At the end of exposed time period, blood samples were collected and various health indicators analyzed. We revealed that biochemical indicators like serum aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), bilirubin, urea, glucose, cholesterol, and triacylglycerol (TG) as well as hematological indicators like red blood cell (RBC), hemoglobin (Hb) and leukocyte (white blood cell) were significantly augmented in the exposed mice as compared to controls. In contrast, serum levels of total protein and albumin were remarkably decreased while serum creatinine and globulin level remained relatively unchanged. Furthermore, the microscopic analysis showed that the histopathological lesions were present on the lung tissue of exposed mice resulting, the alveolar septa and bronchiolar epithelial thickening, emphysema, and atelectasis of lung tissue as well as increased alveolar macrophages. Despite of, liver histopathology of the exposed mice showed same findings with a little deviation. Collectively, our findings propose that inhaling mosquito coil smoke induce significant health hazards on mice model followed by modification of vital health indicators and histological tissuealignment alterations of lung and liver tissues.