ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF PERINDOPRIL ERBUMINE AND AMLODIPINE BESYLATE IN BULK AND TABLET DOSAGE FORM BY HPLC
Journal: Indian Drugs (Vol.50, No. 5)Publication Date: 2013-05-28
Authors : Pattan S. R. Patni A.C. Mali R.A. Patni C.J. Godge R.K. Bhawar H.S. Merekar A.N.; Marathe R.P..;
Page : 32-35
Keywords : *E-mail: shashipattan@yahoo.com;
- ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF PERINDOPRIL ERBUMINE AND AMLODIPINE BESYLATE IN BULK AND TABLET DOSAGE FORM BY HPLC
- DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND INDAPAMIDE IN BULK AND TABLET DOSAGE FORM
- ANALYTICAL METHOD VALIDATION OF RP-HPLC FOR THE ESTIMATION OF ATENOLOL AND AMLODIPINE BESYLATE IN BULK AND TABLET DOSAGE FORMS
- Analytical method development and validation for simultaneous estimation of amlodipine besylate and perindopril arginine in combined pharmaceutical dosage form
- ANALYTICAL ASSAY METHOD VALIDATION AND STRESS DEGRADATION BEHAVIOR OF S (-) AMLODIPINE BESYLATE AND S (-) ATENOLOL FROM BULK AND COMBINED DOSAGE FORM
Abstract
The objective of this present work was to develop and validate analytical method for quantitative determination of perindopril erbumine and amlodipine besylate in bulk as well as in tablet formulation. The chromatographic separation of the two drugs was achieved on a Varian Microsorb-MV 100-5 C18 column (150×4.6mm, 10 μm). The mobile phase constituted of acetonitrile: buffer (65:35) and pH adjusted to 2.6 with ortho- phosphoric Acid was delivered at the flow rate 1mL/min. Detection was performed at 210 nm. Separation was completed within 6 min calibration curves were linear with correlation coefficient between 0.99 to 1.0 over the concentration range of 2.5 to 15 µg/mL of perindopril erbumine and 10 to 60 µg/mL of amlodipine besylate The relative standard deviation (R.S.D.) was found <2.3%. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of perindopril erbumine and amlodipine besylate.
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Last modified: 2020-05-28 20:28:16