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Cholestyramine, A Cost-Effective Yet Efficacious Anti-Dote in Digoxin Toxicity

Journal: International Research Journal of Pharmacy and Medical Sciences (IRJPMS) (Vol.2, No. 4)

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Authors : ; ; ; ; ; ;

Page : 8-10

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Digoxin is a cardiac glycoside obtained from digitalis lanata, is a positive inotropic and negative chronotropic agent. Digoxin works by blocking Na-K ATPase pump resulting in raised intracellular sodium which in turn raise intracellular calcium in the myocytes resulting in increase in inotropic effect [1, 2]. Digoxin causes several adverse effects in overdose leading to both bradyarrhythmias and tachyarrhythmias. The approved antidote, digoxin-specific antibody fragments (DIGIFAB), is costly yet effective option for managing digoxin toxicity [3] we describe the cases in which levels of digoxin fell to acceptable therapeutic levels with the use of Cholestyramine.

Last modified: 2020-06-16 17:53:13