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Sugar Palm Fruits (Arenga pinnata) as Potential Analgesics and Anti-Inflammatory Agent

Journal: Molecular and Cellular Biomedical Sciences (Vol.3, No. 2)

Publication Date:

Authors : ;

Page : 107-14

Keywords : Arenga pinnata; analgesic; anti-inflammatory; acute toxicity;

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Background: Sugar palm fruit (Arenga pinnata) is used for osteoarthritis empirically. It also has antioxidant activity and showed inhibition to lipoxygenase activity. The study about analgesic and anti-inflammatory activities of sugar palm fruit is still limited, this study was initiated to explore analgesic and anti-inflammatory effects of sugar palm fruit ethanol extract (SFEE). Materials and Methods: Acetic acid induced writhing was performed for screening analgesic activity, meanwhile antiinflammatory activity was tested against rat paw edema. Acute toxicity and phytochemical screening were also investigated. Results: The results of phytochemical screening revealed that flavonoids, alkaloids and quinones were present in SFEE. SFEE 50 and 100 mg/kg have analgesic effect and show the anti-oedematogenic effect against paw edema induced by carrageenan. SFEE could significantly decrease the neutrophils numbers as compared to the carrageenan-treated group. Neutrophil activation has been shown to contribute to tissue inflammation and damage. Conclusion: SFEE have analgetic and anti-inflammatory activity.

Last modified: 2020-07-02 12:27:27