COMPARATIVE CLINICAL EVALUATION OF EFFICACY OF SYSTEMICALLY ADMINISTERED ANTIOXIDANT LYCOPENE (STARMUNE®) AND HERBAL (OXITARDTM) AS AN ADJUNCT TO SCALING AND ROOT PLANING IN PATIENTS WITH CHRONIC GINGIVITIS- A RANDOMIZED CLINICAL TRIAL

Background: It is a complex interaction between host-microbial interactions involving cellular and humoral factors and networks of cytokines, chemokine, and some growth factors. Reactive oxygen species (ROS) and the antioxidant defense systems that repair cell, and molecular. Some of the true major reactive oxygen species and free radicals are superoxide, hydroxyl, per hydroxyl, hydrogen peroxide, hypochlorous acid, ozone. There is an equilibrium between increases ROS and decreases antioxidant defense due to oxidative stress. Materials and Method: Total thirty systemically healthy subjects were selected with age group 20±45years. Subjects were randomly assigned into 3 Groups. Group I: 10 patients receiving scaling and root planning alone, Group II: 10 patients receiving StarmuneTM 5mg capsule with SRP twice a day for 2weeks, Group III: 10 patients receiving OxitardTM manufactured by Himalaya Herbals® with SRP twice a day for 2 weeks. Clinical parameters such as Plaque index, gingival index and Sulcus bleeding index was evaluated at baseline after 2weeks. Results: Plaque index on compare from baseline to after 2 weeks no significant difference was observed. While in Gingival index from baseline to 2 weeks more significant difference was observed in group II group III compare to group I. In Sulcus bleeding index from baseline to 2weeks no statistical significant difference were observed Conclusion: The antioxidant Lycopene and Herbal OxitardTM have also shown an additional benefit as an adjunct to non-surgical periodontal therapy.