Neutropenic Enterocolitis Associated with Methotrexate Toxicity

Neutropenic enterocolitis is a serious complication of neutropenia following the administration of antineoplastic and immunosuppressive drugs. It was mostly observed in patients with hematologic malignancies in the past. However, after the increased use of chemotheraphy agents and immunosuppressive therapy, it has been reported more frequently. We present a patient with rheumatoid arthritis (RA) presented with neutropenic enterocolitis induced by methotrexate therapy.