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Contradictory Results between T-SPOT.TB and QFT-3G in Patients with Respiratory Symptoms

Journal: Journal of Clinical Case Studies (Vol.1, No. 6)

Publication Date:

Authors : ;

Page : 1-2

Keywords : Interferon gamma release assay; Negative; Tuberculosis; T-SPOT; QFT;

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A 60-year-old male who presented with cough and fever (case 1), and a 77-year-old female with hemoptysis (case 2) were admitted to IUHW Shioya Hospital. Interferon gamma release assay (IGRA: QFT-3G and T-SPOT.TB) were both performed on each patient; the QFT-3G was positive and T-SPOT.TB was negative in both cases despite different final diagnosis. While case 1 was determined to have active tuberculosis, in case 2 active tuberculosis was eliminated as the diagnosis. The contradictory results in these patients should serve as a reminder to clinicians that they should not rely on the results of IGRA testing for the diagnosis of active tuberculosis.

Last modified: 2020-08-27 22:10:32