EFFECT OF CARBAMAZEPINE ON FETAL KIDNEY

Aims and Objectives: - Carbamazepine is one of the most widely used anti-epileptic drugs among women of child bearing age. This study aims to investigate the morphological and histopathological teratogenic effects of carbamazepine use during pregnancy. Material and Method:-The healthy pregnant female mice were divided into two groups. The control group received equivalent quantity of distilled water by intraperitoneal route on 7th day of gestation. Second group received 30mg/kg of carbamazepine by intraperitoneal route on 7th day of gestation. Fetuses were delivered on the 18th day of gestation by hysterectomy. Each fetus was assessed for histopathological changes of kidney. Results:-Kidney of fetal mice showed edematous changes. Glomeruli appeared to be atrophied and degeneration of epithelial lining of most tubules was evident. Conclusion:-Histopathological changes in kidney of fetus are due to carbamazepine administered to the pregnant mice.