Surveillance of Antimicrobial Resistance of Proteus spp. in a Tertiary Hospital in Nepal

Abstract: Proteus infect various anatomical sites with equal infection propensity in both community and hospital environment. Proteus is usually associated with infection of respiratory tract, urinary tract, eye, ear, nose, skin, burns, throat, and wounds. Methods: The prospective study was conducted from June 2015 to November 2015 in a private hospital in Nepal. All 5,793 clinical samples (urine, pus, swab, and sputum) collected from the suspected infection cases were processed in microbiological procedures to isolate and ide n tif y P r o t e u s s p p . An ti m i c r o b i a l susceptibility test of identied Proteuswas performed by Kirby-Bauer disc diffusion method and the results were interpreted in conformity with the Clinical and Laboratory Standards Institute guideline. Results: Out of the 1, 141 growth positive sample, 2.7%were identied as Proteus spp. with higher isolation from pus samples. P. mirabilis (64.5%) and P. vulgaris(35.5%) were recovered during the study period. Proteus spp. were higher in age group 21 to 40 years. Most Proteus spp. isolates (61.3%), were multidrug resistant. Conclusions: Proteus was predominant in wound infection and multidrug resistance was higher, thus regular surveillance of uncommon pathogens like Proteus spp. is warranted to checkmate these bugs. Keywords: Antimicrobial resistance, multidrug-resistant, Proteus.