Correlation of Ultrasonography and Biopsy in Breast Malignancy

Abstract Ultrasound is a morphologic examination with the help of which we can observe the appearance of different breast masses. Some sonographic criteria aredeveloped for the differentiation of benign and malignant breast mass. Objective: To co-relate sonographic ndings with biopsy ndings in breast malignancy. Methods: A Comparative Cross-sectional study was conducted at INMOL cancer hospital Lahore. During four months of research period 107 female patient suffering with breast lesions were willingly recruited. Examination was performed while using American Institute of Ultrasound in Medicine (AIUM) breast ultrasound guidelines. Ultrasound machines TOSHIBA APLIO 500, XARIO, and NEMIO 20 with linear transducer frequency ranging from 5 to 7 MHz. Data analysis was made using SPSS version 22.0. Results: Benign histologic features were found in 18 lesions (16.8%); malignant histologic features, in 89 (83.2%) lesions. 4 lesions classied as benign were found to be malignant at biopsy. Thus, the classication scheme had a negative predictive value of 86.7% of 98 malignant lesions having malignant sonographic features 13 lesions found benign histologically (27.7% sensitivity & specicity 95.5%). Positive predictive value is 55.5%. Conclusions: Ultrasound is very sensitive for the detection of breast lesion as malignant (95.5%). But it is non- specic having very large number of false positive (72.2%) results. Ultrasound can only give us clue regarding malignant breast mass but its result should always be conrmed with biopsy. Key Words: Ultrasound, Benign Lesion, Malignant lesion, Histopathological ndings