THE LEVEL OF DENDRITIC CELLS IN KIDNEY TRANSPLANT RECIPIENTS IN THE EARLY POSTOPERATIVE PERIOD

Background. Dendritic cells (DC) regulate innate and adaptive immunity and play an important role in the development of tolerance or rejection of the donor organ. Objective. To study the level of dendritic cells in patients after kidney transplantation in the early postoperative period, depending on the functional activity of the donor organ. Material and Methods. Kidney transplantation was performed in 197 recipients. The level of dendritic cells was determined on days 0, 1, 3 and 7 after transplantation. The patients were divided into groups: PGF – those with satisfactory primary graft function, PGD – those with primary graft dysfunction, TR – those with transplant rejection in the postoperative period. The comparison group (CG) consisted of healthy volunteers. Results. Before transplantation, the relative DC level in the PGF group significantly exceeded this indicator in the comparison group. DC level in the PGD and TR groups didn't differ from the value in the comparison group. The absolute amount of DC in the comparison group was significantly higher than in the PGF group, and there were no differences with the PGD and TR groups. On day 3, the relative amount of DC decreased significantly in the PGF and PGD groups, but there was noted an increase in the TR group. On day 7 in the PGF group there was a significant increase in the DC level, in the PGD group there were no changes, in the TR group there was a significant decrease compared with the PGF and PGD groups. The absolute DC values in the TR and PGD groups were gradually decreasing during 7 days, but in the TR group the decrease was more pronounced. Conclusions. Studying the level of dendritic cells in patients after kidney transplantation makes it possible to predict the nature of the course of the early postoperative period