NUANCES OF THE CHOICE OF EXPERIMENTAL ANIMALS FOR MODELING THE HEALING PROCESS OF THE SKIN WOUNDJournal: Journal of the Grodno State Medical University (Vol.18, No. 4)
Publication Date: 2020-10-02
Authors : R. I. Dovnar;
Page : 429-435
Keywords : experimental animal; choice; experience; advantages; distinctive features;
Background. The process of choosing an experimental animal for modeling various processes of the human body, including creating a skin wound, is extremely difficult for the researcher due to the scatter of available data in literary sources and the lack of a single modern reference manual. Aim of the research. To analyze the anatomical, physiological, and economic features of various animal species when they are selected as models for assessing the wound healing properties of local skin wounds. Material and methods. The analysis of 35 Russian- and English-language sources was performed. Results. The presented article outlines the general and distinctive features of various types of applied and promising experimental animals. The advantages and disadvantages of choosing large or small animals are demonstrated, the estimated cost and costs of feeding are shown. Conclusions. When choosing an experimental animal, one should take into account the financial costs, accessibility, simplicity of maintenance, the experience of the researcher, the anatomical and physiological similarity with humans and the information that we want to obtain as a result of the experiment. It is necessary to take into account the anatomical and physiological features of the structure of the skin of the animal in the course of modeling a skin wound and interpreting the obtained data.
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