Overview of the Analysis Methods of Atenolol in Pharmaceutical Preparations and Biological Matrices During 2000 - 2020

Atenolol is one of the most widely used beta-blocker antihypertensive drugs. Therefore, atenolol levels' determination is essential for quality control, either as raw material, in pharmaceutical preparations, biological fluids, or mixtures. Information search on atenolol level determination was conducted through Google Scholar with the keywords "atenolol," "determination," "pharmaceutical preparation," "biological matrix," "mixture." The results showed that atenolol levels could be determined by titrimetric, spectrophotometric, high-performance liquid chromatography, gas chromatography, and electrometry methods. Therefore, it can be concluded that atenolol in the form of raw material can be determined by titrimetric method, spectrophotometry, high-performance liquid chromatography, gas chromatography, and electrometry. Atenolol in pharmaceutical dosage forms can be determined by spectrophotometric methods, high-performance liquid chromatography, gas chromatography, and electrometry. Atenolol in biological fluids can be determined by the high-performance liquid chromatography method. In contrast, atenolol in mixtures with other substances can be determined using the high-performance liquid chromatography method.