HYPERLIPIDEMIA INDUCED BY ATHEROGENIC DIET ENHANCED OXIDATIVE STRESS IN THE KIDNEY AND INFLAMMATORY RESPONSES: AN IN-VIVO STUDY

This study evaluated inflammatory processes and oxidative stress in hyperlipidemic condition induced by high lipid diet. Atherogenic diet prepared by enriching standard diet with 0.2% cholesterol and 0.6% groundnut oil was given to a set of rats while standard diet was given to control rats. Markers of inflammatory processes (interleukin 2 and tumour necrosis factor alpha), oxidative stress index (malondialdehyde), markers of renal damage (urea and creatinine), pro- and antioxidant elements (copper, zinc, iron, manganese, chromium, and calcium) were investigated and compared in the two groups. Results showed increased concentrations of serum total cholesterol, serum triglyceride, serum very low density lipoproteins; tissue total cholesterol and triglycerides in rats given atherogenic diet. In group where atherogenic diet induced high lipids concentrations, enhanced inflammatory processes, oxidative stress in the kidney, as well as higher serum concentrations of pro- and anti-oxidant elements were observed when compared with control rats. Conclusively, hyperlipidemia enhanced oxidative stress in renal tissue and inflammatory reactions.