Overview of Pharmacology and Product Development of Lime (Citrus aurantifolia) Rind

Lime (Citrus aurantifolia) has many benefits for the human body because it contains several phytochemical compounds, namely alkaloids, flavonoids, steroids, and triterpenoids, saponins, tannins, and phenolics. However, many Indonesian people do not know that not only lime fruit has many benefits; the lime peel also has many benefits for the body. This review provides knowledge about the pharmacological activity and development of pharmaceutical products from the lime peel. The keywords Citrus aurantifolia, botany, phytochemical, pharmacology, and product development were searched until November 30, 2020, from journals that can be accessed in databases such as Google Scholar, Science Direct, Scopus, EBSCO, Medline, PubMed, Embase, and other databases. The results showed that this plant has various pharmacological properties such as anticancer, traumatic ulcer medication, tyrosinase inhibitor, antibacterial, and antifungal. The development of pharmaceutical products from the lime peel is for mosquito repellents, hand sanitizers, gel products, and chitosan nanoparticles. In conclusion, Citrus aurantifolia has various pharmacological properties and plays a vital role in human health; therefore, it can be used to produce drugs and cosmetics in the future.