Application of Hydrotrophy in HPLC Hydrotrophic Solution, A Novel Cost Effective and Eco Friendly Mobile Phase for Solubilization of Poorly Water Soluble Drugs

Hydrotrophy is a unique molecular phenomenon that posses the ability to increase the solubility of sparingly soluble and poorly soluble drugs in water. A hydrotrophic solution can be defined as adding a solute, that is Hydrotrope, eg urea to the primary one solvent and is used as mobile phase for HPLC. High solubility, easy availability, cost effectiveness, eco friendly are the major advantages which makes the solubilization technique superior. Here we use paracatamol and diclofenac sodium as example to review and conclude this topic. The current review takes the readers throughout a brief summary and features of hydrotropic agents and their different advances towards HPLC technique. It provides an insight of the future perspectives concerned with HPLC and Hydrotropism. Ahammed Unais V P | P K Sahoo "Application of Hydrotrophy in HPLC; Hydrotrophic Solution, A Novel Cost Effective and Eco-Friendly Mobile Phase for Solubilization of Poorly Water Soluble Drugs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, URL: https://www.ijtsrd.com/papers/ijtsrd38222.pdf Paper URL : https://www.ijtsrd.com/pharmacy/analytical-chemistry/38222/application-of-hydrotrophy-in-hplc-hydrotrophic-solution--a-novel-cost-effective-and-ecofriendly-mobile-phase-for-solubilization-of-poorly-water-soluble-drugs/ahammed-unais-v-p