Selenium Content, Anthelmintic, Antioxidant and Antibacterial Activities of Artocarpus Heterophyllus Lam. From Ubangi Ecoregion in Democratic Republic of the Congo | Biomedgrid llc

Helminths are recognized as a one of major animal and human health problem and the gastrointestinal nematodes become resistant to currently available anthelminthic drugs; therefore, there is a foremost problem in treatment of helminths diseases. The main aim of this study was to assess the anthelminthic, antioxidant and antibacterial activities as well as the mineral content of ethanol and organic acid extracts of Artocarpus heterophyllus Lam leaves. The phytochemical profile and phenolic contents of leaves were determined by thin layer chromatography and the spectrophotometric methods. Phytochemical analysis revealed the presence of flavonoids, phenolic acids, coumarins, anthraquinones, anthocyanins, terpenoids, and the absence of alkaloids in this part of plants. Mineral composition carried out by the method of water and nitric acid and analysis by Inductively Coupled Argon Plasma Optical Emission Spectrometry (ICP-EOS) showed the abundance of different elements namely calcium, iron, potassium and selenium in this plant. Ethanolic extract and organic acid fraction exhibited dose-dependent paralysis of Benhamia rosea in the range concentrations from 0.625 mg/mL to 5 mg/mL in comparison with the standard drug Albendazole. ABTS and DPPH assays showed that these extracts can scavenge free radicals connected with their IC50 values ranging from 17.26 ± 1.66 to 152.1 ± 30.20 mg/m L. Oleanolic acid used such as standard and organic acid fraction showed a weaker capacity to scavenge DPPH radical. Bacteriologic analysis showed that E. coli and S. aureus are not sensitive to Artocarpus heterophyllus Lam. The findings indicated that the anthelminthic and antioxidant activities of Artocarpus heterophyllus leaves support the potential therapeutic interest of this species and could justify its use in Traditional Medicine