Brief Report: Anaplastic Pleomorphic Xanthoastrocytoma Invading the Skull in a Child

We present a case of a tumour in a 12-year-old mentally normal girl, who presented with a painless forehead swelling. Imaging studies demonstrated a large lesion within the right frontal lobe with erosion through the frontal bone. Histological diagnosis met all the criteria of glioblastoma with evidence of florid bone invasion. DNA methylation analysis, however, demonstrated features consistent with anaplastic pleomorphic xanthoastrocytoma. This skull invasion is a very uncommon presentation of gliomas, especially in children, and only a handful of cases have previously been described.