The Neurological, Multisystemic, PolyGenomic and Multipathological Basis of Aging (the ‘Autonomic’ Hypothesis)

The first precise mathematical model of the relationship between sense perception, brain structure and/or function, the autonomic nervous system and/or physiological systems, and cellular and molecular biology was developed by Dr. Igor Gennadyevich Grakov in the period 1981-1997. The aim of this article is to illustrate how such knowledge can be applied to better comprehend how the whole body functions and, in particular, how this can be applied to understand the process (es) responsible for aging and to understand why we ultimately expire. It supports the conclusion that the aging process is associated with the many and various factors which materially influence the stable function of the autonomic nervous system and physiological systems and that our ultimate demise is associated with the inability of the brain to sustain such functional relationships. The author presents this knowledge in the ‘Autonomic Hypothesis' outlined in this report, discusses the significance of the many and various factors which influence the stable and coherent function of the autonomic nervous system, which sustains the body's function and thereby influences the aging process. It incorporates case reports to justify such hypothesis, in particular how this knowledge can be used to screen patient health and optimize longevity.