Effects of exposure to textile dye on serum Alkaline Phosphatase and Gamma Glutamyl Transferase levels in textile industry workers

Background: The textile dyeing industry uses large number of chemicals, acids and dyes. The workers are exposed to these chemicals during their daily work activities. Chronic exposure to these chemicals may have adverse effect on the liver functions, as liver plays an important role in detoxification of these chemicals Objective: To assess serum Alkaline Phosphatase (ALP) and Gamma glutamyl transferase (GGT) levels of the industrials workers exposed to textile dyes. Methods: This cross sectional study was carried out in the Department of Physiology,Dhaka Medical College, Dhaka from July 2016 to June 2017 on 25 apparently healthy male workers aged 20-40 years working in a textile dye factory for 2 years or more. Similar age, sex, BMI & socioeconomically matched 25 apparently healthy non exposed workers were enrolled as control. Serum ALP and GGT levels were estimated by autoanalyzer. For statistical analysis unpaired Student's t-test were performed Results: Serum ALP and GGT levels were significantly higher in textile dye exposed workers than those of control group (p <0.05). Conclusions:This study reveals that exposure to textile dyes have deteriorating effect on liver function.